Creighton finished the 2020-21 season with a 22-9 mark and runner-up finishes in the BIG EAST in both the regular-season and conference tournament. The Bluejays reached the Round of 16 in the NCAA Tournament for the first time since 1974 with postseason victories over UC Santa Barbara and Ohio before falling to eventual national runner-up Gonzaga.
| Date | Opponent | Details | Highlight Reel |
|---|---|---|---|
| 11/29/2020 | North Dakota State | W, 69-58 | Highlights |
| 12/01/2020 | Nebraska-Omaha | W, 94-67 | Highlights |
| 12/04/2020 | Kennesaw State | W, 93-58 | Highlights |
| 12/08/2020 | at #5 Kansas | L, 73-72 | Highlights |
| 12/11/2020 | Nebraska | W, 98-74 | Highlights |
| 12/14/2020 | Marquette | L, 89-84 | Highlights |
| 12/17/2020 | at St. John's | W, 94-76 | Highlights |
| 12/20/2020 | at UConn | W, 76-74 (OT) | Highlights |
| 12/23/2020 | #22 Xavier | W, 66-61 | Highlights |
| 01/02/2021 | at Providence | W, 67-65 | Highlights |
| 01/06/2021 | Seton Hall | W, 89-53 | Highlights |
| 01/09/2021 | St. John's | W, 97-79 | Highlights |
| 01/16/2021 | at Butler | L, 70-66 (OT) | Highlights |
| 01/20/2021 | Providence | L, 74-70 | Highlights |
| 01/23/2021 | UConn | W, 74-66 | Highlights |
| 01/27/2021 | at Seton Hall | W, 85-81 | Highlights |
| 01/30/2021 | at DePaul | W, 69-62 | Highlights |
| 02/03/2021 | Georgetown | L, 86-79 | Highlights |
| 02/06/2021 | at Marquette | W, 71-68 | Highlights |
| 02/09/2021 | at Georgetown | W, 63-48 | |
| 02/13/2021 | #5 Villanova | W, 86-70 | Highlights |
| 02/24/2021 | DePaul | W, 77-53 | Highlights |
| 02/27/2021 | at Xavier | L, 77-69 | Highlights |
| 03/03/2021 | at #10 Villanova | L, 72-60 | Highlights |
| 03/06/2021 | Butler | W, 93-73 | Highlights |
| 03/11/2021 | Butler (Big East Quarterfinal) | W, 87-56 | Highlights |
| 03/12/2021 | UConn (Big East Semifinal) | W, 59-56 | Highlights |
| 03/13/2021 | Georgetown (Big East Championship) | L, 73-48 | Highlights |
| 03/20/2021 | UC Santa Barbara (NCAA Tournament First Round) Christian Bishop's free throws clinch NCAA win | W, 63-62 | Highlights |
| 03/22/2021 | Ohio (NCAA Tournament Second Round) Jays advance to Sweet 16 | W, 72-58 | Highlights |
| 03/28/2021 | #1 Gonzaga (NCAA Tournament Regional Semifinal) | L, 83-65 | Highlights |