Creighton finished the 2017-18 season with a 21-12 record, tied for third place in the Big East Conference with a 10-8 league mark, and returned to the NCAA Tournament for the fifth time in the last seven seasons. For the second straight season, they lost a key player to a season-ending ACL tear when Martin Krampelj (11.9 ppg., 8.1 rpg.) went down on January 17. They were led by the standout backcourt of First Team All-Big East senior Marcus Foster (19.8 ppg.) and Second Team All-Big East choice Khyri Thomas (15.1 ppg.), who was also named Big East Defensive Player of the Year for the second straight season.
| Date | Opponent | Result | |
|---|---|---|---|
| 10/26/2017 | Nebraska-Omaha (Exhib.) | W, 96-67 | Details |
| 11/03/2017 | UNC Pembroke (Exhib.) | W, 93-70 | Details |
| 11/10/2017 | Yale | W, 92-76 | Details |
| 11/12/2017 | Alcorn State | W, 109-72 | Details |
| 11/15/2017 | at #20 Northwestern | W, 92-88 | Details |
| 11/20/2017 | vs #23 UCLA (Hall of Fame Classic) | W, 100-89 | Details |
| 11/21/2017 | vs #22 Baylor (Hall of Fame Classic) | L, 65-59 | Details |
| 11/25/2017 | SIU Edwardsville | W, 103-66 | Details |
| 12/01/2017 | at #15 Gonzaga | L, 91-74 | Details |
| 12/05/2017 | North Dakota | W, 111-68 | Details |
| 12/09/2017 | Nebraska | W, 75-65 | Details |
| 12/15/2017 | Maryland Eastern Shore | W, 87-36 | Details |
| 12/18/2017 | UT Arlington | W, 90-81 | Details |
| 12/20/2017 | USC Upstate | W, 116-62 | Details |
| 12/28/2017 | at #23 Seton Hall | L, 90-84 | Details |
| 12/31/2017 | Providence | W, 83-64 | Details |
| 01/03/2018 | St. John's | W, 78-71 | Details |
| 01/06/2018 | at Georgetown | W, 90-66 | Details |
| 01/09/2018 | Butler | W, 85-74 | Details |
| 01/13/2018 | at #10 Xavier | L, 92-70 | Details |
| 01/17/2018 | #19 Seton Hall | W, 80-63 | Details |
| 01/20/2018 | at Providence | L, 85-71 | Details |
| 01/23/2018 | at St. John's | W, 68-63 | Details |
| 01/27/2018 | Georgetown | W, 85-77 | Details |
| 02/01/2018 | at #1 Villanova | L, 98-78 | Details |
| 02/07/2018 | at DePaul | W, 76-75 | Details |
| 02/10/2018 | #5 Xavier | L, 72-71 | Details |
| 02/13/2018 | Bemidji State (DII) | W, 94-46 | Details |
| 02/17/2018 | Marquette | L, 90-86 | Details |
| 02/20/2018 | at Butler | L, 90-73 | Details |
| 02/24/2018 | #3 Villanova | W, 89-93 (OT) | Details |
| 02/27/2018 | DePaul | W, 82-57 | Details |
| 03/03/2018 | at Marquette | L, 85-81 | Details |
| 03/08/2018 | Providence (Big East Quarterfinal) | L, 72-68 | Details |
| 03/16/2018 | Kansas State (NCAA Tourney) | L, 69-59 | Details |